The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies
Abstract WHO-defined SARS-CoV-2 variants of concern (VOC) drive therapeutics and
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …
A critical analysis of the use of cilgavimab plus tixagevimab monoclonal antibody cocktail (Evusheld™) for COVID-19 prophylaxis and treatment
D Focosi, A Casadevall - Viruses, 2022 - mdpi.com
Evusheld®(tixagevimab+ cilgavimab; AZD7442) was the first anti-Spike monoclonal
antibody (mAb) cocktail designed not only for treatment but also with pre-exposure …
antibody (mAb) cocktail designed not only for treatment but also with pre-exposure …
Deep-learning-enabled protein–protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution
G Wang, X Liu, K Wang, Y Gao, G Li… - Nature Medicine, 2023 - nature.com
Host–pathogen interactions and pathogen evolution are underpinned by protein–protein
interactions between viral and host proteins. An understanding of how viral variants affect …
interactions between viral and host proteins. An understanding of how viral variants affect …
Omicron sublineage BA. 2.75. 2 exhibits extensive escape from neutralising antibodies
DJ Sheward, C Kim, J Fischbach, K Sato… - The Lancet Infectious …, 2022 - thelancet.com
(A) Differences from BA. 2 in BA. 2.75 (orange), and BA. 2.75. 2 (red, underlined), depicted
upon the SARS-CoV-2 BA. 2 receptor binding domain (pdb: 7UB0). Sensitivity of SARS-CoV …
upon the SARS-CoV-2 BA. 2 receptor binding domain (pdb: 7UB0). Sensitivity of SARS-CoV …
Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron
L Wang, M Møhlenberg, P Wang, H Zhou - Cytokine & growth factor …, 2023 - Elsevier
Since its emergence at the end of 2019, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the infection of more than 600 million people worldwide and has …
(SARS-CoV-2) has caused the infection of more than 600 million people worldwide and has …
Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T cell immunity
Evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant has led to the emergence of sublineages with different patterns of neutralizing …
variant has led to the emergence of sublineages with different patterns of neutralizing …
Genetic and structural data on the SARS-CoV-2 Omicron BQ. 1 variant reveal its low potential for epidemiological expansion
The BQ. 1 SARS-CoV-2 variant, also known as Cerberus, is one of the most recent Omicron
descendant lineages. Compared to its direct progenitor BA. 5, BQ. 1 has some additional …
descendant lineages. Compared to its direct progenitor BA. 5, BQ. 1 has some additional …
Clinical characteristics and novel mutations of omicron subvariant XBB in Tamil Nadu, India–a cohort study
ST Selvavinayagam, SJ Karishma… - The Lancet Regional …, 2023 - thelancet.com
Background Despite the continued vaccination efforts, there had been a surge in
breakthrough infections, and the emergence of the B. 1.1. 529 omicron variant of SARS-CoV …
breakthrough infections, and the emergence of the B. 1.1. 529 omicron variant of SARS-CoV …
Durability of neutralization against Omicron subvariants after vaccination and breakthrough infection
KL Zhu, XL Jiang, BD Zhan, XJ Wang, X Xia, GP Cao… - Cell reports, 2023 - cell.com
Booster immunizations and breakthrough infections can elicit severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant neutralizing activity. However …
syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant neutralizing activity. However …
The SARS‐CoV‐2 Omicron variant and its multiple sub‐lineages: transmissibility, vaccine development, antiviral drugs, monoclonal antibodies, and strategies for …
Abstract The Omicron (B. 1.1. 529), fifth variant of concern (VOC) of SARS‐CoV‐2, initially
identified following a steep increase in COVID‐19 cases in Southern Africa in November …
identified following a steep increase in COVID‐19 cases in Southern Africa in November …