Oroxylin A: A promising flavonoid for prevention and treatment of chronic diseases

A Sajeev, M Hegde, S Girisa, TN Devanarayanan… - Biomolecules, 2022 - mdpi.com
There have been magnificent advancements in the understanding of molecular mechanisms
of chronic diseases over the past several years, but these diseases continue to be a …

Pyroptosis in the retinal neurovascular unit: new insights into diabetic retinopathy

C Meng, C Gu, S He, T Su, T Lhamo, D Draga… - Frontiers in …, 2021 - frontiersin.org
Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM)
and remains the leading cause of visual impairment in working-aged people. DR is related …

Hyperglycemia induces meibomian gland dysfunction

Y Guo, H Zhang, Z Zhao, X Luo… - … & Visual Science, 2022 - iovs.arvojournals.org
Purpose: Patients diagnosed with diabetes are inclined to have abnormalities on stability of
tear film and disorder of meibomian gland (MG). This study aims to explore the pathological …

Activation of the GABA-alpha receptor by berberine rescues retinal ganglion cells to attenuate experimental diabetic retinopathy

W Fang, X Huang, K Wu, Y Zong, J Yu, H Xu… - Frontiers in Molecular …, 2022 - frontiersin.org
Purpose The aim of this study was to investigate the role and mechanism of berberine (BBR)
in the protection of injured retinal ganglion cells (RGCs) in diabetic retinopathy (DR) …

Rodent models of diabetic retinopathy as a useful research tool to study neurovascular cross-talk

K Polewik, M Kosek, D Jamrozik, I Matuszek… - Biology, 2023 - mdpi.com
Simple Summary Diabetic retinopathy is a progressive complication of diabetes leading to
vision loss. About one in three diabetic patients has some degree of diabetic retinopathy …

Optic nerve regeneration in diabetic retinopathy: potentials and challenges ahead

S Wu, X Mo - International journal of molecular sciences, 2023 - mdpi.com
Diabetic retinopathy (DR), the most common microvascular compilation of diabetes, is the
leading cause of vision loss and blindness worldwide. Recent studies indicate that retinal …

Elastin turnover in ocular diseases: A special focus on age-related macular degeneration

S Navneet, B Rohrer - Experimental eye research, 2022 - Elsevier
The extracellular matrix (ECM) and its turnover play a crucial role in the pathogenesis of
several inflammatory diseases, including age-related macular degeneration (AMD). Elastin …

New insights into oxidative stress and immune mechanisms involved in age-related macular degeneration tackled by novel therapies

MC Potilinski, PS Tate, VE Lorenc, JE Gallo - Neuropharmacology, 2021 - Elsevier
The prevalence of age-related macular degeneration (AMD) has increased in the last years.
Although anti-VEGF agents have improved the prognosis of exudative AMD, dry AMD has …

HspB4/αA-crystallin modulates neuroinflammation in the retina via the stress-specific inflammatory pathways

M Nath, Y Shan, AM Myers, PE Fort - Journal of Clinical Medicine, 2021 - mdpi.com
Purpose: We have previously demonstrated that HspB4/αA-crystallin, a molecular
chaperone, plays an important intrinsic neuroprotective role during diabetes, by its …

Towards a new biomarker for diabetic retinopathy: exploring RBP3 structure and retinoids binding for functional imaging of eyes in vivo

V Kaushik, L Gessa, N Kumar, H Fernandes - International Journal of …, 2023 - mdpi.com
Diabetic retinopathy (DR) is a severe disease with a growing number of afflicted patients,
which places a heavy burden on society, both socially and financially. While there are …