COVID-19: immunopathogenesis and Immunotherapeutics

L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected …

Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports

S Najjar, A Najjar, DJ Chong, BK Pramanik… - Journal of …, 2020 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a highly infectious pandemic caused by a
novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It …

Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection

L Montefusco, M Ben Nasr, F D'Addio, C Loretelli… - Nature …, 2021 - nature.com
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …

Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

VC Veiga, JAGG Prats, DLC Farias, RG Rosa… - bmj, 2021 - bmj.com
Objective To determine whether tocilizumab improves clinical outcomes for patients with
severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open label trial …

Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical
illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure …

[HTML][HTML] Compromised humoral functional evolution tracks with SARS-CoV-2 mortality

T Zohar, C Loos, S Fischinger, C Atyeo, C Wang… - Cell, 2020 - Elsevier
The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress
in the absence of well-defined correlates of immunity. While neutralization has been linked …

Comparison of nonhuman primates identified the suitable model for COVID-19

S Lu, Y Zhao, W Yu, Y Yang, J Gao, J Wang… - Signal transduction and …, 2020 - nature.com
Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains
challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] Neutrophils and COVID-19: The road so far

LHA Cavalcante-Silva, DCM Carvalho… - International …, 2021 - Elsevier
The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-
19, a pandemic disease. This disease is characterized by acute respiratory distress …

Impact of cardiovascular disease and risk factors on fatal outcomes in patients with COVID-19 according to age: a systematic review and meta-analysis

SA Bae, SR Kim, MN Kim, WJ Shim, SM Park - Heart, 2021 - heart.bmj.com
Objective Previous studies that evaluated cardiovascular risk factors considered age as a
potential confounder. We aimed to investigate the impact of cardiovascular disease (CVD) …

Peripheral nervous system manifestations associated with COVID-19

S Andalib, J Biller, M Di Napoli, N Moghimi… - Current neurology and …, 2021 - Springer
Abstract Purpose of Review The present review discusses the peripheral nervous system
(PNS) manifestations associated with coronavirus disease 2019 (COVID-19). Recent …