Nonalcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging
evidence points toward metabolic inflammation as a key process in the fatty liver that …

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the
setting of insulin resistance. The current evidence suggests that genetic predisposition, and …

Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes
mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death …

Although the currently available antidiabetic medications are effective in managing
hyperglycemia, vascular complications are common in diabetic patients. Cohort studies …

Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease characterized by the
destruction of insulin‐secreting pancreatic β cells. In humans with T1D and in nonobese …

Apoptosis is probably the main form of β-cell death in both type 1 diabetes mellitus (T1DM)
and T2DM. In T1DM, cytokines contribute to β-cell destruction through nuclear factor-κB (NF …

OBJECTIVE—SIRT1, a class III histone/protein deacetylase, is known to interfere with the
nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function …

" It is perhaps today, where a certain underevaluation-well, even disrespect-of scientific
research is growing-useful again and again to refer to the fact of how well suited the …

Both common forms of diabetes have an inflammatory pathogenesis in which immune and
metabolic factors converge on interleukin-1β as a key mediator of insulin resistance and β …

At present, proven clinical treatments but no cures are available for diabetes, a global
epidemic with a huge economic burden. Transplantation of islets of Langerhans by their …