Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

d-Amino-acid oxidase (DAO) catalyzes the oxidative deamination of d-amino acids. DAO is
present in a wide variety of organisms and has important roles. Here, we review the …

Several attempts have been made to enhance N-methyl-D-aspartate (NMDA) receptor
function in schizophrenia, but they have yielded mixed results. Luvadaxistat, a D-amino acid …

Feasible peripheral biomarker for Alzheimer's disease (AD) is lacking. Dysregulation of N-
methyl-D-aspartate (NMDA) receptor is implicated in the pathogenesis of AD. D-amino acid …

Abstract The second messenger inositol 1, 4, 5‐trisphosphate (IP3) is paramount for signal
transduction in biological cells, mediating Ca2+ release from the endoplasmic reticulum. Of …

Histamine intolerance occurs when there is an imbalance between histamine production
and the capacity for histamine degradation. Diamine oxidase (DAO) is the main enzyme for …

Numerous studies over the last several years have shown that d-amino acids, especially d-
serine, have been related to brain and neurological disorders. Acknowledged neurological …

The endogenous amino acids serine and aspartate occur at high concentrations in free D-
form in mammalian organs, including the central nervous system and endocrine glands. D …

Histamine intolerance arises when there is a disparity between the production of histamine
and the body's ability to break it down. In the gastrointestinal tract, the primary enzyme …

In the wake of recent advances in artificial intelligence research, precision psychiatry using
machine learning techniques represents a new paradigm. The D-amino acid oxidase (DAO) …