Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during
REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more …

Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …

Genetic variants associated with complex traits are primarily noncoding, and their effects on
gene-regulatory activity remain largely uncharacterized. To address this, we profile …

Alzheimer's disease (AD) is the most common cause of dementia in older adults.
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …

Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …

A deeper understanding of genetic regulation and functional mechanisms underlying
genetic associations with complex traits and diseases is impeded by cellular heterogeneity …

To study mental illness and health, in the past researchers have often broken down their
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …

Single-cell transcriptomic studies have identified a conserved set of neocortical cell types
from small postmortem cohorts. We extended these efforts by assessing cell type variation …