DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

R Huang, PK Zhou - Signal transduction and targeted therapy, 2021 - nature.com
Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Development and challenges in the discovery of 5-HT1A and 5-HT7 receptor ligands

D Singh, P Singh, P Srivastava, D Kakkar, M Pathak… - Bioorganic …, 2023 - Elsevier
Abstract Serotonin (5-hydroxytryptamine) is a small molecule that acts both in the central
and peripheral nervous system as a neurotransmitter and a hormone, respectively …

Identification of the prognostic significance of somatic mutation-derived LncRNA signatures of genomic instability in lung adenocarcinoma

W Geng, Z Lv, J Fan, J Xu, K Mao, Z Yin… - Frontiers in cell and …, 2021 - frontiersin.org
Background: Lung adenocarcinoma (LUAD) is a highly heterogeneous tumor with
substantial somatic mutations and genome instability, which are emerging hallmarks of …

Binding and mechanistic studies of 5-HT7 specific benzothiazolone derivatives with bovine serum albumin: Spectroscopic and in silico studies

D Singh, L Kaur, AJ Rahman, P Singh, AK Tiwari… - Journal of Molecular …, 2022 - Elsevier
Serotonin, commonly known as 5-Hydroxytryptamine, or 5-HT, is a neurotransmitter having a
single amine group and is distributed throughout the peripheral nervous system (PNS) and …

Synthesis, characterization, in vitro, in silico and in vivo investigations and biological assessment of Knoevenagel condensate β-diketone Schiff base transition …

B Marimuthu, S Saravanaselvam… - Journal of …, 2023 - Taylor & Francis
A novel Schiff base ligand was synthesized by the Knoevenagel condensation of β-diketone
(obtained from substituted Curcumin and Cuminaldehyde) and 4-amino antipyrine. Metal …

Employing Molecular Docking Calculations for the Design of Alkyl (2-Alcoxy-2-Hydroxypropanoyl)-L-Tryptophanate Derivatives as Potential Inhibitors of 11β …

D Quiroga - Reactions, 2023 - mdpi.com
In this paper, we presented the design by computational tools of novel alkyl (2-alcoxy-2-
hydroxypropanoyl)-L-tryptophanate derivatives, which can be potential inhibitors of 11β …

On a Novel Approach to Investigation and Evaluation of the Efficacy of DNA-Binding Radioprotectors

MA Kolyvanova, NS Lifanovsky, EA Nikitin… - High Energy …, 2024 - Springer
A fundamental possibility of using the ability of low-molecular-weight DNA molecules to form
optically active cholesteric liquid-crystalline dispersions (CLCDs) to estimate the efficacy of …

Research progress on radioprotective effects of bee products

X Zhang, H Song, X Tang, S Wang, J Li… - International Journal of …, 2021 - Taylor & Francis
Radiation exposure is an on going and serious threat in military and public health concern.
There is an unmet need for effective preventative or mitigative treatments against radiation …

Exploring the toxic effects and mechanism of methoxylated polybrominated diphenyl ethers (MeO‐PBDEs) on thyroxine‐binding globulin (TBG): Synergy between …

M Huang, X Huang, Y Zuo, Z Yi, H Liu - Luminescence, 2021 - Wiley Online Library
The interaction mechanism between thyroxine‐binding globulin (TBG) and three
methoxylated polybrominated diphenyl ethers (MeO‐PBDEs) was analyzed by steady‐state …

Системи генетичної оцінки впливу факторів навколишнього середовища

S Kislyak, O Dugan, O Yalovenko - Innovative Biosystems and …, 2024 - ibb.kpi.ua
One of the most important components of environmental protection is the development of
hygiene standards aimed at shielding the human population from the adverse effects of …