The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

Virtually all types of cardiovascular diseases are associated with pathological activation of
the innate immune system. The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD) …

Numerous studies demonstrate that neuroinflammation is a key player in the progression of
Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore …

Interleukin-1β (IL-1β)–mediated inflammation suppresses antitumor immunity, leading to the
generation of a tumor-permissive environment, tumor growth, and progression. Here, we …

Background Inflammation is critical in the pathophysiology of atherosclerosis (AS). The aim
of this study was to investigate the protective effect of salvianolic acid B (Sal B) on AS and to …

Background Parkinson's disease (PD) is characterized by a progressive degeneration of
dopaminergic neurons, which leads to irreversible loss of peripheral motor functions. Death …

Inspired by the recent advancements in understanding the binding mode of sulfonylurea-
based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors …

More than a decade ago IL-1 blockade was suggested as an add-on therapy for the
treatment of cancer. This proposal was based on the overall safety record of anti-IL-1 …

Nucleotide-binding oligomerization domain NOD-like receptors (NLRs) are conserved
cytosolic pattern recognition receptors (PRRs) that track the intracellular milieu for the …

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide.
Inflammation and oxidative stress play critical roles in progression of various types of CVD …