The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

Transcription and translation require a high concentration of potassium across the entire tree
of life. The conservation of a high intracellular potassium was an absolute requirement for …

Focal brain injuries (in particular, stroke and traumatic brain injury) induce with high
probability the development of delayed (months, years) cognitive and depressive …

Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of
the stress response and regulate many physiological processes, including metabolism and …

We studied the role of the mineralocorticoid receptor (MR) in the signaling that promotes
atrial fibrosis. Left atrial myocardium of patients with atrial fibrillation (AF) exhibited 4-fold …

Background Microglia, the resident macrophage-like cells in the brain, regulate innate
immune responses in the CNS to protect neurons. However, excessive activation of …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …

Mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) are descended from an
ancestral corticoid receptor (CR). To date, the earliest CR have been found in lamprey and …

In this review, we highlight the specific metabolic effects of fructose consumption that are
involved in the development of metabolic syndrome non-alcoholic fatty liver disease and its …

The mineralocorticoid hormone aldosterone (Aldo) has been intensively studied for its ability
to influence both the physiology and pathophysiology of the cardiovascular system. Indeed …