Primary aldosteronism, caused by autonomous secretion of aldosterone by the adrenals, is
estimated to account for at least 5% of hypertension cases. Hypertension explains the …

Methylenedioxymethamphetamine (MDMA,'ecstasy') and methylphenidate are widely used
psychoactive substances. MDMA primarily enhances serotonergic neurotransmission, and …

The mineralocorticoid aldosterone is a key regulator of water and electrolyte homeostasis.
Numerous recent developments have advanced the field of mineralocorticoid pharmacology …

Corticosteroids are secreted by the adrenal glands and control the functions of adipose
tissue via the activation of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) …

Stress is a normal response to situational pressures or demands. Exposure to stress
activates the hypothalamic-pituitary-adrenal (HPA) axis and leads to the release of …

There is a growing body of experimental and clinical evidence supporting mineralocorticoid
receptor (MR) activation as a powerful mediator of renal damage in laboratory animals and …

Although multiple steroid ligands of the glucocorticoid, mineralocorticoid, and progestin
families bind to and regulate the activity of mineralocorticoid receptors (MRs), the responses …

C11-oxy C19 and C11-oxy C21 steroids have been identified as novel steroids but their
function remains unclear. This study aimed to investigate the pre-receptor regulation of C11 …

Licorice-induced pseudoaldosteronism is a common adverse effect in traditional Japanese
Kampo medicine, and 3-monoglucuronyl glycyrrhetinic acid (3MGA) was considered as a …

Corticosteroids influence the development and function of the heart and its response to
injury and pressure overload via actions on glucocorticoid (GR) and mineralocorticoid (MR) …