MR (mineralocorticoid receptor) activation in the heart plays a central role in the
development of cardiovascular disease, including heart failure. The MR is present in many …

Since the discovery of aldosterone over 50 years ago, many facets of its biological action
have been elucidated. 1 Aldosterone is the primary endogenous agonist ligand for the …

BACKGROUND: Recently it has been suggested that excessive glucocorticoiddependent
choroidal mineralocorticoid receptor (MR) activation may be involved in the pathogenesis of …

FDA-approved mineralocorticoid receptor (MR) antagonists are used to treat heart failure.
We have recently demonstrated efficacy of MR antagonists for skeletal muscles in addition to …

The response to a panel of steroids by the mineralocorticoid receptor (MR) from Amur
sturgeon and tropical gar, two basal ray-finned fish, expressed in HEK293 cells was …

Bupropion is widely used for treatment of depression and as a smoking-cessation drug.
Despite more than 20 years of therapeutic use, its metabolism is not fully understood. While …

Mineralocorticoid receptor (MR) antagonists (MRA), also referred to as aldosterone blockers,
are now well-recognized for their clinical benefit in patients who have heart failure (HF) with …

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of
metabolic syndrome. We previously showed that pharmacological inhibition of 11β-HSD1 …

Abstract 11β‐Hydroxysteroid dehydrogenases (11β‐HSD) control the intracellular
concentrations of glucocorticoids: 11β‐HSD1 converts the inactive cortisone to the active …

Mineralocorticoid and glucocorticoid receptors are closely related steroid hormone receptors
that regulate gene expression through many of the same hormone response elements …