The enzyme 11 β-hydroxysteroid dehydrogenase type 2 (11 β-HSD2) has an essential role
in aldosterone target tissues, conferring aldosterone selectivity for the mineralocorticoid …

Loss of mineralocorticoid receptor signaling selectively in cardiomyocytes can ameliorate
cardiac fibrotic and inflammatory responses caused by excess mineralocorticoids. The aim …

Objectives Increased intra‐adipose cortisol is thought to promote obesity, but few human
studies have investigated intra‐adipose glucocorticoid hormones and none have …

Activity and selectivity assessment of new bi-aryl amide 11β-hydroxysteroid dehydrogenase
1 (11β-HSD1) inhibitors, prepared in a modular manner via Suzuki cross-coupling, are …

Exposure to the environmental pollutants organotins is of toxicological concern for the
marine ecosystem and sensitive human populations, including pregnant women and their …

The cellular response to the adrenal steroid aldosterone is mediated by the
mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily of ligand …

Abstract Analysis of a genome-scale RNA interference screen of host factors affecting
herpes simplex virus type 1 (HSV-1) revealed that the mineralocorticoid receptor (MR) …

Aldosterone (Aldo) has been intensively studied for years since its isolation by Simpson and
Tait in the 1950s. Interestingly, although most early research around Aldo's actions focused …

Background: Aldosterone, through its actions on Mineralcorticosteroid Receptors (MR),
controls fluid and electrolyte balance, but also exerts various direct deleterious actions on …

Background Impaired corticosteroid action caused by genetic and environmental influence,
including exposure to hazardous xenobiotics, contributes to the development and …