Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases

BF Becker, M Jacob, S Leipert… - British journal of …, 2015 - Wiley Online Library
The endothelial glycocalyx has a profound influence at the vascular wall on the transmission
of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic …

[HTML][HTML] Endothelial glycocalyx impairment in disease: focus on hyaluronan shedding

S Dogné, B Flamion - The American journal of pathology, 2020 - Elsevier
Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the extracellular matrix. It is present
in the endothelial glycocalyx covering the apical surface of endothelial cells. The endothelial …

[HTML][HTML] Glycocalyx degradation in ischemia-reperfusion injury

Z Abassi, Z Armaly, SN Heyman - The American journal of pathology, 2020 - Elsevier
The glycocalyx is a layer coating the luminal surface of vascular endothelial cells. It is vital
for endothelial function as it participates in microvascular reactivity, endothelium interaction …

Human glycocalyx shedding: systematic review and critical appraisal

RG Hahn, V Patel, RO Dull - Acta Anaesthesiologica …, 2021 - Wiley Online Library
Abstracts Background The number of studies measuring breakdown products of the
glycocalyx in plasma has increased rapidly during the past decade. The purpose of the …

The glycocalyx—linking albuminuria with renal and cardiovascular disease

TJ Rabelink, D De Zeeuw - Nature reviews nephrology, 2015 - nature.com
Albuminuria is commonly used as a marker of kidney disease progression, but some
evidence suggests that albuminuria also contributes to disease progression by inducing …

Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study

A Rovas, J Sackarnd, J Rossaint, S Kampmeier… - Critical Care, 2021 - Springer
Background The availability of handheld, noninvasive sublingual video-microscopes allows
for visualization of the microcirculation in critically ill patients. Recent studies demonstrate …

The role of endothelial glycocalyx in health and disease

O Yilmaz, B Afsar, A Ortiz, M Kanbay - Clinical kidney journal, 2019 - academic.oup.com
The endothelium is the largest organ in the body and recent studies have shown that the
endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity …

Assessing microvascular function in humans from a chronic disease perspective

AJHM Houben, RJH Martens… - Journal of the American …, 2017 - journals.lww.com
Microvascular dysfunction (MVD) is considered a crucial pathway in the development and
progression of cardiometabolic and renal disease and is associated with increased …

Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion

DH Lee, MJC Dane, BM Van Den Berg, MGS Boels… - PloS one, 2014 - journals.plos.org
Changes in endothelial glycocalyx are one of the earliest changes in development of
cardiovascular disease. The endothelial glycocalyx is both an important biological modifier …

Postoperative microcirculatory perfusion and endothelial glycocalyx shedding following cardiac surgery with cardiopulmonary bypass

NAM Dekker, D Veerhoek, NJ Koning… - …, 2019 - Wiley Online Library
We investigated microcirculatory perfusion disturbances following cardiopulmonary bypass
in the early postoperative period and whether the course of these disturbances mirrored …