Viral entry inhibitors protect against SARS-CoV-2-induced neurite shortening in differentiated SH-SY5Y cells

M Mignolet, J Gilloteaux, N Halloin, M Gueibe… - Viruses, 2023 - mdpi.com
The utility of human neuroblastoma cell lines as in vitro model to study neuro-invasiveness
and neuro-virulence of SARS-CoV-2 has been demonstrated by our laboratory and others …

SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell–derived human …

JM Luczo, SJ Edwards, K Ardipradja, WW Suen… - Journal of …, 2024 - Springer
Sarbecoviruses such as SARS and SARS-CoV-2 have been responsible for two major
outbreaks in humans, the latter resulting in a global pandemic. While sarbecoviruses …

Molecular Relay Stations in Membrane Nanotubes: IRSp53 Involved in Actin-Based Force Generation

T Madarász, B Brunner, H Halász, E Telek… - International Journal of …, 2023 - mdpi.com
Membrane nanotubes are cell protrusions that grow to tens of micrometres and functionally
connect cells. Actin filaments are semi-flexible polymers, and their polymerisation provides …

Single particle tracking reveals SARS-CoV-2 regulating and utilizing dynamic filopodia for viral invasion

Y Zhang, X Zhang, Z Li, W Zhao, H Yang, S Zhao… - Science Bulletin, 2023 - Elsevier
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry mechanism
has been explored, little is known about how SARS-CoV-2 regulates the subcellular …

Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission

CF Yang, CC Liao, HW Hsu, JJ Liang… - Journal of Biomedical …, 2023 - Springer
Background Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. hACE2 …

Nervous system‐related tropism of SARS‐CoV‐2 and autoimmunity in COVID‐19 infection

R Weissert - European Journal of Immunology, 2024 - Wiley Online Library
The effects of SARS‐CoV‐2 in COVID‐19 on the nervous system are incompletely
understood. SARS‐CoV‐2 can infect endothelial cells, neurons, astrocytes, and …

Ebola virus uses tunneling nanotubes as an alternate route of dissemination

MA Djurkovic, CG Leavitt, E Arnett… - The Journal of …, 2023 - academic.oup.com
Ebola virus (EBOV) disease is marked by rapid virus replication and spread. EBOV enters
the cell by macropinocytosis and replicates in the cytoplasm, and nascent virions egress …

Modified host defence peptide GF19 slows TNT-mediated spread of corneal herpes simplex virus serotype I infection

NC Thathapudi, N Callai-Silva, K Malhotra, S Basu… - Scientific Reports, 2024 - nature.com
Corneal HSV-1 infections are a leading cause of infectious blindness globally by triggering
tissue damage due to the intense inflammation. HSV-1 infections are treated mainly with …

A nano-platform combats the “attack” and “defense” of cytoskeleton to block cascading tumor metastasis

J Tao, Y Yao, M Huang, J Wu, J Lyu, Q Li, L Li… - Journal of Controlled …, 2024 - Elsevier
The cytoskeleton facilitates tumor cells invasion into the bloodstream via vasculogenic
mimicry (VM) for “attack”, and protects cells against external threats through cytoskeletal …

Tunneling Nanotubes Mediate KRas Transport: Inducing Tumor Heterogeneity and Altering Cellular Membrane Mechanical Properties

Y Zheng, J Li, D Xu, L Liu, Y Li, J Yi, J Dong, D Pang… - Acta Biomaterialia, 2024 - Elsevier
Mutation in oncogene KRas plays a crucial role in the occurrence and progression of
numerous malignant tumors. Malignancy involves changes in cell mechanics for extensive …