Sex and gender in neurodevelopmental conditions
Health-related conditions often differ qualitatively or quantitatively between individuals of
different birth-assigned sexes and gender identities, and/or with different gendered …
different birth-assigned sexes and gender identities, and/or with different gendered …
[PDF][PDF] Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder?
Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a"
female protective effect"(FPE) envisions males and females have" differing thresholds" …
female protective effect"(FPE) envisions males and females have" differing thresholds" …
Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
The contributions of rare inherited and polygenic risk to ASD in multiplex families
M Cirnigliaro, TS Chang, SA Arteaga… - Proceedings of the …, 2023 - National Acad Sciences
Autism spectrum disorder (ASD) has a complex genetic architecture involving contributions
from both de novo and inherited variation. Few studies have been designed to address the …
from both de novo and inherited variation. Few studies have been designed to address the …
[HTML][HTML] Genomic findings in schizophrenia and their implications
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
Mental health challenges faced by autistic people
MC Lai - Nature Human Behaviour, 2023 - nature.com
Mental health challenges impede the well-being of autistic people. This Review outlines
contributing neurodevelopmental and physical health conditions, rates and developmental …
contributing neurodevelopmental and physical health conditions, rates and developmental …
[PDF][PDF] Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency
Preclinical models of neurodevelopmental disorders typically use single inbred mouse
strains, which fail to capture the genetic diversity and symptom heterogeneity that is common …
strains, which fail to capture the genetic diversity and symptom heterogeneity that is common …
[HTML][HTML] The foundations of autistic flourishing
E Pellicano, M Heyworth - Current Psychiatry Reports, 2023 - Springer
Abstract Purpose of Review All people—including Autistic people—deserve to live
flourishing lives. But what does a flourishing life look like for Autistic people? We suggest …
flourishing lives. But what does a flourishing life look like for Autistic people? We suggest …
[HTML][HTML] Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome
SHANK3-related Phelan-McDermid syndrome (PMS) is caused by a loss of the distal part of
chromosome 22, including SHANK3, or by a pathological SHANK3 variant. There is an …
chromosome 22, including SHANK3, or by a pathological SHANK3 variant. There is an …
[HTML][HTML] A systematic review of non-coding RNA genes with differential expression profiles associated with autism spectrum disorders
Aims To identify differential expression of shorter non-coding RNA (ncRNA) genes
associated with autism spectrum disorders (ASD). Background ncRNA are functional …
associated with autism spectrum disorders (ASD). Background ncRNA are functional …