Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials

A Amstutz, B Speich, F Mentré, CS Rueegg… - The Lancet …, 2023 - thelancet.com
Background Interpretation of the evidence from randomised controlled trials (RCTs) of
remdesivir in patients treated in hospital for COVID-19 is conflicting. We aimed to assess the …

The rapid rise of SARS‐CoV‐2 Omicron subvariants with immune evasion properties: XBB. 1.5 and BQ. 1.1 subvariants

D Ao, X He, W Hong, X Wei - MedComm, 2023 - Wiley Online Library
As the fifth variant of concern of the SARS‐CoV‐2 virus, the Omicron variant (B. 1.1. 529)
has quickly become the dominant type among the previous circulating variants worldwide …

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

T Tamura, J Ito, K Uriu, J Zahradnik, I Kida… - Nature …, 2023 - nature.com
Abstract In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified,
and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that …

Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ. 1.1 variant

J Ito, R Suzuki, K Uriu, Y Itakura, J Zahradnik… - Nature …, 2023 - nature.com
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These
variants convergently acquired amino acid substitutions at critical residues in the spike …

[HTML][HTML] Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

P Zhou, G Song, H Liu, M Yuan, W He, N Beutler, X Zhu… - Immunity, 2023 - cell.com
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly
protective vaccines against novel pandemic coronaviruses and to more effectively respond …

SARS-CoV-2 BA. 2.86 enters lung cells and evades neutralizing antibodies with high efficiency

L Zhang, A Kempf, I Nehlmeier, A Cossmann, A Richter… - Cell, 2024 - cell.com
Summary BA. 2.86, a recently identified descendant of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 2 sublineage, contains∼ 35 mutations …

Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB. 1.5

M Hoffmann, P Arora, I Nehlmeier, A Kempf… - Cellular & Molecular …, 2023 - nature.com
Since late 2022, the share of infections caused by the SARS-CoV-2 lineage XBB. 1.5 has
gradually increased in the United States, resulting in XBB. 1.5 becoming the dominating …

Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron

L Wang, M Møhlenberg, P Wang, H Zhou - Cytokine & growth factor …, 2023 - Elsevier
Since its emergence at the end of 2019, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the infection of more than 600 million people worldwide and has …

Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

L Guo, S Lin, Z Chen, Y Cao, B He, G Lu - Signal Transduction and …, 2023 - nature.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …

Coronavirus disease 2019 convalescent plasma outpatient therapy to prevent outpatient hospitalization: a meta-analysis of individual participant data from 5 …

AC Levine, Y Fukuta, MA Huaman, J Ou… - Clinical Infectious …, 2023 - academic.oup.com
Background Outpatient monoclonal antibodies are no longer effective and antiviral
treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in …