Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of
extracellular amyloid-β (Aβ)-containing plaques followed by the formation of neurofibrillary …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Gene and protein expression data provide useful resources for understanding brain
function, but little is known about the lipid composition of the brain. Here, we perform …

Complex diseases are characterized by spatiotemporal cellular and molecular changes that
may be difficult to comprehensively capture. However, understanding the spatiotemporal …

While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear,
other brain-resident myeloid cells remain less well understood. By dissecting border regions …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Microglia maintain homeostasis in the central nervous system through phagocytic clearance
of protein aggregates and cellular debris. This function deteriorates during ageing and …

Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature
of the retina. The development of this disease is associated with the action of inflammatory …

Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow
cognitive decline have not yet been successful. Many of these approaches have targeted the …

Alzheimer's disease (AD) and type 2 diabetes (T2D) are both diseases with increasing
prevalence in aging populations. T2D, characterized by insulin resistance and defective …