Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

In the last few years, more and more scientists have suggested and confirmed that
epigenetic regulators are tightly connected and form a comprehensive network of regulatory …

Gene regulation plays a critical role in the cellular processes that underlie human health and
disease. The regulatory relationship between transcription factors (TFs), key regulators of …

Abstract Histone deacetylase 5 (HDAC5) belongs to class II HDAC subfamily and is reported
to be increased in the kidneys of diabetic patients and animals. However, little is known …

Cancer is a complex disease involving alterations of multiple processes, with both genetic
and epigenetic features contributing as core factors to the disease. In recent years, it has …

Therapies that target oncogenes and immune checkpoint molecules constitute a major
group of treatments for metastatic melanoma. A mutation in BRAF (BRAF V600E) affects …

Epigenetic research has the potential to improve our understanding of the pathogenesis of
cancer, specifically non-small-cell lung cancer, and support our efforts to personalize the …

Autophagy is conserved cellular machinery that degrades un-usable proteins and cellular
components and has a crucial role in the pathogenesis and drug resistance of various …

Histone deacetylase 5 (HDAC5) is a class II HDAC. Aberrant expression of HDAC5 has
been observed in multiple cancer types, and its functions in cell proliferation and invasion …

Enhancement of hematopoietic stem cell (HSC) homing and engraftment is clinically critical,
especially for cord blood (CB) hematopoietic cell transplantation. Here we report that …