Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

Apolipoprotein E (APOE) is the major cholesterol carrier in the brain, affecting various
normal cellular processes including neuronal growth, repair and remodeling of membranes …

Astrocytes regulate the response of the central nervous system to disease and injury and
have been hypothesized to actively kill neurons in neurodegenerative disease,,,,–. Here we …

Genetic variants of TREM2, a protein expressed selectively by microglia in the brain, are
associated with Alzheimer's disease (AD). Starting from an unbiased protein microarray …

Apolipoprotein E gene (APOE) alleles may shift the onset of Alzheimer's disease (AD)
through apoE protein isoforms changing the probability of amyloid-β (Aβ) accumulation. It …

APOE and Trem2 are major genetic risk factors for Alzheimer's disease (AD), but how they
affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific …

Abstract Background Apolipoprotein E (apoE) is a major carrier of cholesterol and essential
for synaptic plasticity. In brain, it's expressed by many cells but highly expressed by the …

Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

Cholesterol is a multifacetted molecule. First, it serves as an essential membrane
component, as a cofactor for signaling molecules and as a precursor for steroid hormones; …

ABCA1 is an ATP-binding cassette protein that transports cellular cholesterol and
phospholipids onto high density lipoproteins (HDL) in plasma. Lack of ABCA1 in humans …