[HTML][HTML] m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
[HTML][HTML] Targeting the RNA m6A modification for cancer immunotherapy
Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …
and its dysregulation drives aberrant transcription and translation programs that promote …
[PDF][PDF] Targeting FTO suppresses cancer stem cell maintenance and immune evasion
Fat mass and obesity-associated protein (FTO), an RNA N 6-methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
[HTML][HTML] Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal Transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
[PDF][PDF] Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia
FTO, an mRNA N 6-methyladenosine (m 6 A) demethylase, was reported to promote
leukemogenesis. Using structure-based rational design, we have developed two promising …
leukemogenesis. Using structure-based rational design, we have developed two promising …
The Critical Role of RNA m6A Methylation in Cancer
Since the identification of the first RNA demethylase and the establishment of methylated
RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has …
RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has …
[PDF][PDF] R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis
Summary R-2-hydroxyglutarate (R-2HG), a metabolite produced by mutant isocitrate
dehydrogenases (IDHs), was recently reported to exhibit anti-tumor activity. However, its …
dehydrogenases (IDHs), was recently reported to exhibit anti-tumor activity. However, its …
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
[HTML][HTML] RNA methylation and cancer treatment
To this date, over 100 different types of RNA modification have been identified. Methylation
of different RNA species has emerged as a critical regulator of transcript expression. RNA …
of different RNA species has emerged as a critical regulator of transcript expression. RNA …