RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
Y Niu, Z Lin, A Wan, H Chen, H Liang, L Sun, Y Wang… - Molecular cancer, 2019 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most pervasive
modification in mRNA, and has been considered as a new layer of epigenetic regulation on …
modification in mRNA, and has been considered as a new layer of epigenetic regulation on …
The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance
Q Lan, PY Liu, JL Bell, JY Wang, S Hüttelmaier… - Cancer research, 2021 - AACR
Abstract RNA N6-methyladenosine (m6A) modification occurs in approximately 25% of
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events
Abstract Background N6-methyladenosine (m 6 A) modification of RNA influences
fundamental aspects of RNA metabolism and m 6 A dysregulation is implicated in various …
fundamental aspects of RNA metabolism and m 6 A dysregulation is implicated in various …
Dynamic regulation and functions of mRNA m6A modification
S Wang, W Lv, T Li, S Zhang, H Wang, X Li… - Cancer cell …, 2022 - Springer
Abstract N 6-Methyladenosine (m6A), the most abundant internal modification associated
with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the …
with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the …
FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
RNA N6-methyladenosine modification in cancers: current status and perspectives
Abstract N 6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
Liver cancer is a common cancer worldwide. Although the etiological factors of liver
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …
[HTML][HTML] Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma
Y Yang, J Cai, X Yang, K Wang, K Sun, Z Yang… - Molecular Therapy, 2022 - cell.com
Type 2 diabetes mellitus (DM2) is associated closely with non-alcoholic fatty liver disease
(NAFLD) by affecting lipid metabolism, which may lead to non-alcoholic steatohepatitis …
(NAFLD) by affecting lipid metabolism, which may lead to non-alcoholic steatohepatitis …
N6-methyladenosine links RNA metabolism to cancer progression
Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …
development of antibody-based sequencing technologies and the findings of m6A-related …
Mechanism of RNA modification N6-methyladenosine in human cancer
Z Zhou, J Lv, H Yu, J Han, X Yang, D Feng, Q Wu… - Molecular cancer, 2020 - Springer
Since the breakthrough discoveries of DNA and histone modifications, the field of RNA
modifications has gained increasing interest in the scientific community. The discovery of N6 …
modifications has gained increasing interest in the scientific community. The discovery of N6 …