RNA methylations in human cancers
RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …
regulating various biological processes, such as RNA transcription, splicing, structure …
Glutathione‐bioimprinted nanoparticles targeting of N6‐methyladenosine FTO demethylase as a strategy against leukemic stem cells
Abstract The N6‐methyladenosine (m6A) demethylase FTO plays an oncogenic role in
acute myeloid leukemia (AML). Despite the promising recent progress for developing some …
acute myeloid leukemia (AML). Despite the promising recent progress for developing some …
Roles of RNA methylation by means of N6-methyladenosine (m6A) in human cancers
S Wang, C Sun, J Li, E Zhang, Z Ma, W Xu, H Li, M Qiu… - Cancer letters, 2017 - Elsevier
Reversible methylation by means of N6-methyladenosine (m 6 A) is the most prevalent
internal modification in mammalian mRNA. This RNA chemical mark is created by proteins …
internal modification in mammalian mRNA. This RNA chemical mark is created by proteins …
The dynamic epitranscriptome: N6-methyladenosine and gene expression control
KD Meyer, SR Jaffrey - Nature reviews Molecular cell biology, 2014 - nature.com
Abstract N 6-methyladenosine (m6A) is a modified base that has long been known to be
present in non-coding RNAs, ribosomal RNA, polyadenylated RNA and at least one …
present in non-coding RNAs, ribosomal RNA, polyadenylated RNA and at least one …
Chemical Inhibitors Targeting the Oncogenic m6A Modifying Proteins
Y Huang, W Xia, Z Dong, CG Yang - Accounts of Chemical …, 2023 - ACS Publications
Conspectus Epigenetics is brought to RNA, introducing a new dimension to gene
expression regulation. Among numerous RNA modifications, N 6-methyladenosine (m6A) is …
expression regulation. Among numerous RNA modifications, N 6-methyladenosine (m6A) is …
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors
Abstract N 6-methyladenosine (m6A) on mRNAs is critical for various biological processes,
yet whether m6A regulates drug resistance remains unknown. Here we show that …
yet whether m6A regulates drug resistance remains unknown. Here we show that …
N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis
Z Lin, AH Wan, L Sun, H Liang, Y Niu, Y Deng, S Yan… - Molecular Therapy, 2023 - cell.com
N6-methyladenosine (m 6 A) is the most pervasive RNA modification and is recognized as a
novel epigenetic regulation in RNA metabolism. Although the m 6 A modification involves …
novel epigenetic regulation in RNA metabolism. Although the m 6 A modification involves …
Role of N6-methyladenosine modification in cancer
As the most abundant internal modification in eukaryotic messenger RNAs identified, N 6-
methyladenosine (m 6 A) has been shown recently to play essential roles in various normal …
methyladenosine (m 6 A) has been shown recently to play essential roles in various normal …
Rational Design and Optimization of m6A-RNA Demethylase FTO Inhibitors as Anticancer Agents
S Huff, IR Kummetha, L Zhang, L Wang… - Journal of medicinal …, 2022 - ACS Publications
Aberrant regulation of N 6-methyladenosine (m6A) RNA modification has been implicated in
the progression of multiple diseases, including cancer. Previously, we identified a small …
the progression of multiple diseases, including cancer. Previously, we identified a small …
m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
SW Yue, HL Liu, HF Su, C Luo, HF Liang, BX Zhang… - Molecular Cancer, 2023 - Springer
Glycolytic reprogramming is one of the most important features of cancer and plays an
integral role in the progression of cancer. In cancer cells, changes in glucose metabolism …
integral role in the progression of cancer. In cancer cells, changes in glucose metabolism …