[HTML][HTML] Reactive oxygen species induced pathways in heart failure pathogenesis and potential therapeutic strategies

A Mongirdienė, L Skrodenis, L Varoneckaitė… - Biomedicines, 2022 - mdpi.com
With respect to structural and functional cardiac disorders, heart failure (HF) is divided into
HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) …

The role of EGFR in vascular AT1R signaling: from cellular mechanisms to systemic relevance

M Gekle, V Dubourg, G Schwerdt, RA Benndorf… - Biochemical …, 2023 - Elsevier
The epidermal growth factor receptor (EGFR) belongs to the ErbB-family of receptor tyrosine
kinases that are of importance in oncology. During the last years, substantial evidence …

[HTML][HTML] A differential signature of circulating miRNAs and cytokines between COVID-19 and community-acquired pneumonia uncovers novel physiopathological …

P Martínez-Fleta, P Vera-Tomé… - Frontiers in …, 2022 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) pneumonia is a life-threatening infectious disease,
especially for elderly patients with multiple comorbidities. Despite enormous efforts to …

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1, 3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with …

SA Abdel-Aziz, ES Taher, P Lan, GF Asaad… - Bioorganic …, 2021 - Elsevier
A new series of pyrimidine-5-carbonitrile derivatives 8a-p carrying the 1, 3-thiazole moiety
has been designed and synthesized as novel anti-inflammatory EGFR inhibitors with cardiac …

[HTML][HTML] Kaempferol prevents against Ang II-induced cardiac remodeling through attenuating Ang II-induced inflammation and oxidative stress

Y Du, J Han, H Zhang, J Xu, L Jiang… - Journal of Cardiovascular …, 2019 - journals.lww.com
Heart failure characterized by cardiac remodeling is a global problem. Angiotensin II (Ang II)
induces cardiac inflammation and oxidative stress, which also is implicated in the …

[HTML][HTML] Proteomic and metabolomic correlates of healthy dietary patterns: the Framingham Heart Study

ME Walker, RJ Song, X Xu, RE Gerszten, D Ngo… - Nutrients, 2020 - mdpi.com
Data on proteomic and metabolomic signatures of healthy dietary patterns are limited. We
evaluated the cross-sectional association of serum proteomic and metabolomic markers with …

[HTML][HTML] Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway

A Abulizi, J Simayi, M Nuermaimaiti, M Han… - Biomedicine & …, 2023 - Elsevier
We identified the effective components and the underlying mechanisms of Quince (Cydonia
oblonga Mill, COM) extract against atherosclerosis. The effective components of COM …

[HTML][HTML] Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation

JS Cavalcante, IMC Brito, LA De Oliveira, LC De Barros… - Toxins, 2022 - mdpi.com
The clinical manifestations of Bothrops atrox envenoming involve local and systemic
changes, among which edema requires substantial attention due to its ability to progress to …

[HTML][HTML] Mitigation of Gastric Damage Using Cinnamomum cassia Extract: Network Pharmacological Analysis of Active Compounds and Protection Effects in Rats

JH Lee, HJ Kwak, D Shin, HJ Seo, SJ Park, BH Hong… - Plants, 2022 - mdpi.com
Gastritis is a common disease worldwide that is caused by various causes such as eating
habits, smoking, severe stress, and heavy drinking, as well as Helicobacter pylori infections …

Luteolin attenuates atherosclerosis via modulating signal transducer and activator of transcription 3-mediated inflammatory response

X Ding, L Zheng, B Yang, X Wang… - Drug design, development …, 2019 - Taylor & Francis
Background Inflammatory factors play a crucial role throughout the development and
progression of atherosclerosis, which has been considered as a chronic vascular …