[HTML][HTML] Advances in peripheral blood biomarkers of patients with Alzheimer's disease: Moving closer to personalized therapies

G Ferretti, S Serafini, A Angiolillo, P Monterosso… - Biomedicine & …, 2023 - Elsevier
Recently, measurable peripheral biomarkers in the plasma of patients with Alzheimer's
disease (AD) have gained considerable clinical interest. Several studies have identified one …

The emerging role of IL‐38 in diseases: A comprehensive review

W Chen, S Xi, Y Ke, Y Lei - Immunity, Inflammation and …, 2023 - Wiley Online Library
Abstract Introduction Interleukin‐38 (IL‐38) is a new type of anti‐inflammatory cytokine,
which is mainly expressed in the immunity‐related organs and is involved in various …

Recent advances in Alzheimer's disease pathogenesis and therapeutics from an immune perspective

TD Nguyen, LN Dang, JH Jang, S Park - Journal of Pharmaceutical …, 2023 - Springer
Abstract Background The prevalence of Alzheimer's disease, the most common type of
dementia, is continuously increasing. Many recent reports have indicated that immune …

Circulating biomarkers of inflammaging and Alzheimer's disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite …

AM Abbatecola, A Giuliani, L Biscetti, L Scisciola… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a rapidly growing global concern due to a consistent rise of the
prevalence of dementia which is mainly caused by the aging population worldwide. An early …

The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease

M Culjak, MN Perkovic, S Uzun… - Current Alzheimer …, 2020 - ingentaconnect.com
Background: Sporadic Alzheimer's Disease (AD) is assumed to be associated with different
biological/genetic vulnerability, as well as with neuroinflammation, mediated by cytokines …

Nicotinic acetylcholine receptors and microglia as therapeutic and imaging targets in Alzheimer's disease

K Takata, H Kimura, D Yanagisawa, K Harada… - Molecules, 2022 - mdpi.com
Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of
Alzheimer's disease (AD), but attenuation in choline signaling, including decreased nicotinic …

Physical exercise prevents amyloid β1−40-induced disturbances in NLRP3 inflammasome pathway in the hippocampus of mice

JM Rosa, A Camargo, IAV Wolin, MP Kaster… - Metabolic Brain …, 2021 - Springer
Amyloid beta (Aβ), one of the main hallmarks of Alzheimer's Disease (AD), may stimulate
pattern recognition receptors (PRR) such as the NLRP3 inflammasome, inducing a pro …

Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma

JG Kiang, JT Smith, G Cannon, MN Anderson, C Ho… - Cell & Bioscience, 2020 - Springer
Background Compared to radiation injury alone (RI), radiation injury combined wound (CI)
further enhances acute radiation syndrome and subsequently mortality. We previously …

Patchouli alcohol ameliorates the learning and memory impairments in an animal model of Alzheimer's disease via modulating SIRT1

QQ Xu, ZR Su, Z Hu, W Yang, YF Xian, ZX Lin - Phytomedicine, 2022 - Elsevier
Background Alzheimer's disease (AD) is one of the most prevalent neurodegenerative
diseases. Patchouli alcohol (PA), a major active ingredient isolated from Pogostemonis …

Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome

S Hu, X Wan, X Li, X Wang - Frontiers in Physiology, 2022 - frontiersin.org
Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis,
obesity, diabetes, depression, and Alzheimer's disease, which usually release pyroptosis …