Deciphering the Warburg effect: metabolic reprogramming, epigenetic remodeling, and cell dedifferentiation
A century ago, Otto Heinrich Warburg made a seminal discovery now known as the Warburg
effect. This metabolic signature, prevalent across all cancer cells, is characterized by the …
effect. This metabolic signature, prevalent across all cancer cells, is characterized by the …
[HTML][HTML] Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine
J Ousingsawat, R Centeio, N Reyne, A McCarron… - Scientific Reports, 2024 - nature.com
Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in
secretory epithelial cells of airways and intestine. Previous studies provided evidence for a …
secretory epithelial cells of airways and intestine. Previous studies provided evidence for a …
[HTML][HTML] A mitochondrial perspective on noncommunicable diseases
Y Zheng, J Zhang, X Zhu, Y Wei, W Zhao, S Si, Y Li - Biomedicines, 2023 - mdpi.com
Mitochondria are the center of energy metabolism in eukaryotic cells and play a central role
in the metabolism of living organisms. Mitochondrial diseases characterized by defects in …
in the metabolism of living organisms. Mitochondrial diseases characterized by defects in …
[HTML][HTML] Induction of oxidative stress and ferroptosis in triple-negative breast cancer cells by niclosamide via blockade of the function and expression of SLC38A5 and …
M Mathew, S Sivaprakasam… - Antioxidants, 2024 - mdpi.com
The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative
breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and …
breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and …
Targeting the epithelial–mesenchymal transition (EMT) pathway with combination of Wnt inhibitor and chalcone complexes in lung cancer cells
Non‐small cell lung cancer (NSCLC) is the most common type of the lung cancer. Despite
development in treatment options in NSCLC, the overall survival ratios is still poor due to …
development in treatment options in NSCLC, the overall survival ratios is still poor due to …
[HTML][HTML] High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach
CM Hsu, KC Chang, TM Chuang, ML Chu, PW Lin… - Cancers, 2023 - mdpi.com
Simple Summary Diffuse large B-cell lymphoma (DLBCL) is a prevalent hematological
malignancy which is characterized by rapid cancer cell growth and aggressive progression …
malignancy which is characterized by rapid cancer cell growth and aggressive progression …
[HTML][HTML] Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells
T Kulthawatsiri, Y Kittirat, J Phetcharaburanin… - PeerJ, 2023 - peerj.com
Background Niclosamide is an oral anthelminthic drug that has been used for treating
tapeworm infections. Its mechanism involves the disturbance of mitochondrial membrane …
tapeworm infections. Its mechanism involves the disturbance of mitochondrial membrane …
[HTML][HTML] Preparation of PLGA microspheres loaded with niclosamide via microfluidic technology and their inhibition of Caco-2 cell activity in vitro
Y Tai, M Tian, Y Chen, P You, X Song, B Xu… - Frontiers in …, 2023 - frontiersin.org
Niclosamide (NIC) is a multifunctional drug that regulates various signaling pathways and
biological processes. It is widely used for the treatment of cancer, viral infections, and …
biological processes. It is widely used for the treatment of cancer, viral infections, and …
[HTML][HTML] The Warburg effect drives dedifferentiation through epigenetic reprogramming
H Jiang, M Jedoui, J Ye - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
German biochemist and cell physiologist, Otto H. Warburg (Figure 1), made a
groundbreaking discovery in 1923. Specifically, tumors were shown to consume large …
groundbreaking discovery in 1923. Specifically, tumors were shown to consume large …
[HTML][HTML] Conformational and Chiroptical Properties of Salicylamide-Based Peptidomimetics
I Raich, K Pauk, A Imramovsky, J Jampílek - Symmetry, 2024 - mdpi.com
Optical rotation (OR), the most frequently used chiroptical method, is used for the
characterization of newly synthesized or isolated compounds. Computational predictions of …
characterization of newly synthesized or isolated compounds. Computational predictions of …