Autism spectrum disorders (ASD) affect about 1% of the population and are strongly
associated with gastrointestinal diseases creating shortcomings in quality of life. Multiple …

Neurodevelopmental disorders (NDDs) are associated with a wide range of clinical features,
affecting multiple pathways involved in brain development and function. Recent advances in …

Genetic variants in ZNF536 contribute to the risk for neuropsychiatric disorders such as
schizophrenia, autism, and others. The role of this putative transcriptional repressor in brain …

Microdeletion of a 3Mb region encompassing 45 protein-coding genes at chromosome
22q11. 2 (22q11. 2DS) predisposes individuals to multiple neurodevelopmental disorders …

Despite intensive research into the etiopathogenesis of autism spectrum disorder (ASD),
limited progress has been achieved so far. Among the plethora of models seeking to clarify …

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a complex
etiology. Recent evidence suggests that dopamine plays a crucial role in neural …

Previous studies have identified the exposure to ubiquitous environmental endocrine
disruptors may be a risk factor of neurological disorders. However, the effects of fluorene-9 …

The exact mechanisms of the development of autism, a multifactorial neurological disorder,
are not clear. The pathophysiology of autism is complex, and investigations at the cellular …

Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder. The
heterogeneity of ASD poses great challenges for its research and clinical translation. On the …

Methods: We used CRISPR/Cas9 to introduce frameshift mutations in the syngap1a and
syngap1b zebrafish duplicates (syngap1ab) and validated these stable models for Syngap1 …