Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …

Highlights•Itaconate modulates metabolic pathways relevant to tumor growth.•Itaconate
influences immune cell function and TME.•Itaconate inhibits TET methylcytosine …

Itaconate is a metabolite that synthesized from cis-aconitate in mitochondria and transported
into the cytosol to exert multiple regulatory effects in macrophages. However, the …

The metabolism in eukaryotic cells is a highly ordered system involving various cellular
compartments, which fluctuates based on physiological rhythms. Organelles, as the smallest …

Immune cells undergo rapid and extensive metabolic changes during inflammation. In
addition to contributing to energetic and biosynthetic demands, metabolites can also …

Although engineering bacterial sensors have outstanding advantages in reflecting the actual
bioavailability and continuous monitoring of pollutants, the potential escape risk of …

Cytokine storm syndrome (CSS) is a life-threatening systemic inflammatory syndrome
involving innate immune hyperactivity triggered by various therapies, infections, and …

Immune cell activation triggers signaling cascades leading to transcriptional reprogramming,
but also strongly impacts on the cell's metabolic activity to provide energy and biomolecules …

Proteolytic enzymes are one of the important biomarkers that enable the early diagnosis of
several diseases, such as cancers. A specific proteolytic enzyme selectively degrades a …

Background: Evolutionarily, immune response is a complex mechanism that protects the
host from internal and external threats. Pattern-recognition receptors (PRRs) recognize …