[HTML][HTML] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
DNA methylation (DNAm)-based biomarkers of aging have been developed for many
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
R Xu, W Wei, M Krawczyk, W Wang, H Luo, K Flagg… - Nature materials, 2017 - nature.com
An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
Spectrum of clonal hematopoiesis in VEXAS syndrome
F Gutierrez-Rodrigues, Y Kusne… - Blood, The Journal …, 2023 - ashpublications.org
Abstract Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is
caused by somatic mutations in UBA1 (UBA1 mut) and characterized by heterogenous …
caused by somatic mutations in UBA1 (UBA1 mut) and characterized by heterogenous …
Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
DL McCartney, JL Min, RC Richmond, AT Lu… - Genome biology, 2021 - Springer
Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …
and correlate with morbidity and mortality. Consequently, identification of genetic and …
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up
Biological age measurements (BAs) assess aging-related physiological change and predict
health risks among individuals of the same chronological age (CA). Multiple BAs have been …
health risks among individuals of the same chronological age (CA). Multiple BAs have been …
Biological age predictors
J Jylhävä, NL Pedersen, S Hägg - EBioMedicine, 2017 - thelancet.com
The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …
ongoing for over three decades, and until recently, largely without success. Advances in the …
Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.
Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …
development, although existing evidence for this varies. We present a meta-analysis and …
[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …
morbidity and mortality making vaccination a crucial mean to safeguard this population …
Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
H Luo, Q Zhao, W Wei, L Zheng, S Yi, G Li… - Science translational …, 2020 - science.org
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …