[HTML][HTML] Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning
There is an urgent need to develop molecular biomarkers of brain age in order to advance
our understanding of age related neurodegeneration. Recently, we developed a highly …
our understanding of age related neurodegeneration. Recently, we developed a highly …
Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: do they measure the same thing?
The geroscience hypothesis posits that therapies to slow biological processes of aging can
prevent disease and extend healthy years of life. To test such “geroprotective” therapies in …
prevent disease and extend healthy years of life. To test such “geroprotective” therapies in …
[HTML][HTML] DNA methylation-based measures of biological age: meta-analysis predicting time to death
Estimates of biological age based on DNA methylation patterns, often referred to as
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
Background: The DNA methylation-based 'epigenetic clock'correlates strongly with
chronological age, but it is currently unclear what drives individual differences. We examine …
chronological age, but it is currently unclear what drives individual differences. We examine …
Human PBMC scRNA-seq–based aging clocks reveal ribosome to inflammation balance as a single-cell aging hallmark and super longevity
H Zhu, J Chen, K Liu, L Gao, H Wu, L Ma, J Zhou… - Science …, 2023 - science.org
Quantifying aging rate is important for evaluating age-associated decline and mortality. A
blood single-cell RNA sequencing dataset for seven supercentenarians (SCs) was recently …
blood single-cell RNA sequencing dataset for seven supercentenarians (SCs) was recently …
[HTML][HTML] Aging and DNA methylation
M Jung, GP Pfeifer - BMC biology, 2015 - Springer
In this Opinion article, we summarize how changes in DNA methylation occur during aging
in mammals and discuss examples of how such events may contribute to the aging process …
in mammals and discuss examples of how such events may contribute to the aging process …
[HTML][HTML] The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis
Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …
there is considerable between-person variation in the rate of ageing and individual …
[HTML][HTML] Deep biomarkers of human aging: application of deep neural networks to biomarker development
One of the major impediments in human aging research is the absence of a comprehensive
and actionable set of biomarkers that may be targeted and measured to track the …
and actionable set of biomarkers that may be targeted and measured to track the …
Forensic DNA phenotyping: predicting human appearance from crime scene material for investigative purposes
M Kayser - Forensic Science International: Genetics, 2015 - Elsevier
Forensic DNA Phenotyping refers to the prediction of appearance traits of unknown sample
donors, or unknown deceased (missing) persons, directly from biological materials found at …
donors, or unknown deceased (missing) persons, directly from biological materials found at …
[HTML][HTML] Human iPSC-based modeling of late-onset disease via progerin-induced aging
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity
back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset …
back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset …