Immunotherapy harnesses the inherent immune system in the body to generate systemic
antitumor immunity, offering a promising modality for defending against cancer. However …

Innate immunity is an intrinsic baseline defense in cells, with its earliest origins in bacteria,
and with key roles in defense against pathogens and in the activation of B and T cell …

The Trp metabolite l-kynurenine (KYN) accumulates in numerous solid tumours and
mediates potent immunosuppression. Bacterial kynureninases (KYNases), which …

Background Previous studies have shown that functional systemic immunity is required for
the efficacy of PD-1/PD-L1 blockade immunotherapies in cancer. Hence, systemic …

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while
coping with nutrient availability. A better understanding of how systemic metabolism impacts …

Coronavirus disease 2019 (COVID-19) is a serious epidemic, characterized by potential
mutation and can bring about poor vaccine efficiency. It is evidenced that patients with …

The Aryl hydrocarbon receptor (AhR) is a xenobiotic and endobiotic receptor, which
regulates many cellular processes from contaminant metabolism to immunomodulation …

Overexpression of Lin28 is detected in various cancers with involvement in the self-renewal
process and cancer stem cell generation. In the present study, we evaluated how the Lin28 …

Purine nucleotides and nucleosides are involved in various human physiological and
pathological mechanisms. The pathological deregulation of purinergic signaling contributes …

Intrinsic metabolism shapes the immune environment associated with immune suppression
and tolerance in settings such as organ transplantation and cancer. However, little is known …