[HTML][HTML] The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation

AL Comer, M Carrier, MÈ Tremblay… - Frontiers in cellular …, 2020 - frontiersin.org
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Genetic architecture of schizophrenia: a review of major advancements

SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …

The genetic architecture of schizophrenia: review of large-scale genetic studies

H Kato, H Kimura, I Kushima, N Takahashi… - Journal of Human …, 2023 - nature.com
Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …

[HTML][HTML] Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia

B Ben-Azu, EC Del Re, J VanderZwaag… - Frontiers in Cellular …, 2023 - frontiersin.org
Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature accelerated in probands affected by schizophrenia (SCZ). Evidence shows …

Polygenic risk score as clinical utility in psychiatry: a clinical viewpoint

M Ikeda, T Saito, T Kanazawa, N Iwata - Journal of Human Genetics, 2021 - nature.com
Genome-wide association studies (GWASs) have detected many susceptible variants for
common diseases, including psychiatric disorders. However, because of the small effect size …

Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis

YX Zhang, LP Yang, C Gai, CC Cheng, Z Guo… - Frontiers in …, 2022 - frontiersin.org
Background Psychiatric disorders have seriously affected human life, one of the risk genes
related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene …

[HTML][HTML] Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK biobank

M Bracher-Smith, E Rees, G Menzies, JTR Walters… - Schizophrenia …, 2022 - Elsevier
Abstract Machine learning (ML) holds promise for precision psychiatry, but its predictive
performance is unclear. We assessed whether ML provided added value over logistic …

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients

LE Herzog, L Wang, E Yu, S Choi, Z Farsi… - Translational …, 2023 - nature.com
Schizophrenia is a heterogeneous psychiatric disorder with a strong genetic basis, whose
etiology and pathophysiology remain poorly understood. Exome sequencing studies have …

Modeling psychotic disorders: environment x environment interaction

K Murlanova, MV Pletnikov - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Schizophrenia is a major psychotic disorder with multifactorial etiology that includes
interactions between genetic vulnerability and environmental risk factors. In addition …

The role of nicotinic cholinergic neurotransmission in delusional thinking

M Caton, ELM Ochoa, FJ Barrantes - NPJ schizophrenia, 2020 - nature.com
Delusions are a difficult-to-treat and intellectually fascinating aspect of many psychiatric
illnesses. Although scientific progress on this complex topic has been challenging, some …