Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA
damage that cause genomic instability that lead to cancer development. The highest fidelity …

Lactylation is a lactate-induced post-translational modification best known for its roles in
epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers.
Characterization of genetic alterations will improve our understanding and therapies for this …

Increasing evidence demonstrates that DNA damage and genome instability play a crucial
role in ageing. Mammalian cells have developed a wide range of complex and well …

Abstract α-Synuclein is a crucial element in the pathogenesis of Parkinson's disease (PD)
and related neurological diseases. Although numerous studies have presented potential …

The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1
(MRN) complex is critical for the initiation of DNA damage response and DSB end resection …

PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …

High-risk human papillomaviruses (HPVs) are associated with several human cancers.
HPVs are small, DNA viruses that rely on host cell machinery for viral replication. The HPV …

Simple Summary Recent practice-changing trials have highlighted the importance of
polyadenosine diphosphate-ribose polymerase inhibitors (PARPi) in metastatic castrate …