Chromatin states play a key role in shaping overall cellular states and fates. Building a
complete picture of the functional state of chromatin in cells requires the co-detection of …

For decades, DNA chips, also known as DNA microarrays, have been extensively utilized for
high-throughput gene expression analysis and single nucleotide polymorphism (SNP) …

Chronic disease processes are marked by cell-specific transcriptomic and epigenomic
changes. Single nucleus joint RNA-and ATAC-seq offers an opportunity to study the gene …

Abstract single-cell sequencing methods have enabled the profiling of multiple types of
molecular readouts at cellular resolution, and recent developments in spatial barcoding, in …

Genetic and epigenetic variations in regulatory enhancer elements increase susceptibility to
a range of pathologies. Despite recent advances, linking enhancer elements to target genes …

Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. High
level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying …

Gene regulatory networks are now at the forefront of precision biology, which can help
researchers better understand how genes and regulatory elements interact to control …

The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …

Cis-regulatory elements (CREs) are critical in coordinating the regulation of gene
expression. Understanding how CREs evolve represents a challenging endeavor. Here, we …

Drug discovery is a generally inefficient and capital-intensive process. For
neurodegenerative diseases (NDDs), the development of novel therapeutics is particularly …