Metastatic bone disease is a complex condition resulting from the migration and colonization
of cancer cells from their primary site to the bone microenvironment, where they typically …

Simple Summary This review describes how osteocytes, the most abundant cells in bone,
act in cancers that grow in bone. It summarizes how cancer cells reprogram osteocytes to …

Breast cancer predominantly metastasizes to the skeleton. Mechanical loading is reliably
anabolic in bone, and also inhibits bone metastatic tumor formation and bone loss in vivo …

Chromatin organization, whose malfunction causes various diseases including cancer, is
fundamentally controlled by cohesin. While cancer cells have been found with mutated or …

Piezo1 (2010) was identified as a mechanically activated cation channel capable of sensing
various physical forces, such as tension, osmotic pressure, and shear force. Piezo1 …

Patients undergoing cancer treatments and/or suffering from metastatic bone lesions
experience various skeletal-related events (SREs), substantially reducing functional …