The role of m6A RNA methylation in cancer metabolism

Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …

The roles and implications of RNA m6A modification in cancer

X Deng, Y Qing, D Horne, H Huang… - Nature Reviews Clinical …, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

H Weng, F Huang, Z Yu, Z Chen, E Prince, Y Kang… - Cancer Cell, 2022 - cell.com
Summary N 6-Methyladenosine (m 6 A) modification and its modulators play critical roles
and show promise as therapeutic targets in human cancers, including acute myeloid …

[HTML][HTML] The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer

D Ramesh-Kumar, S Guil - Seminars in Cancer Biology, 2022 - Elsevier
RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …

Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application

F Zhang, H Liu, M Duan, G Wang, Z Zhang… - Journal of hematology & …, 2022 - Springer
The tumor microenvironment (TME), which is regulated by intrinsic oncogenic mechanisms
and epigenetic modifications, has become a research hotspot in recent years. Characteristic …

[HTML][HTML] The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer

CY Sun, D Cao, BB Du, CW Chen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
RNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …

Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential

TY Zhu, LL Hong, ZQ Ling - Biomarker research, 2023 - Springer
Abstract N6-methyladenosine (m6A) is the most prevalent and well-characterized internal
chemical modification in eukaryotic RNA, influencing gene expression and phenotypic …

m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism

SW Yue, HL Liu, HF Su, C Luo, HF Liang, BX Zhang… - Molecular Cancer, 2023 - Springer
Glycolytic reprogramming is one of the most important features of cancer and plays an
integral role in the progression of cancer. In cancer cells, changes in glucose metabolism …

[HTML][HTML] N6-methyladenosine modification and metabolic reprogramming of digestive system malignancies

X Cai, C Liang, M Zhang, Y Xu, Y Weng, X Li, W Yu - Cancer Letters, 2022 - Elsevier
Abstract N 6-methyladenosine (m6A) is a eukaryotic post-transcriptional modification
involved in cell growth and developmental processes, including RNA transcription …

First small-molecule inhibitors targeting the RNA-binding protein IGF2BP2/IMP2 for cancer therapy

C Dahlem, A Abuhaliema, SM Kessler… - ACS chemical …, 2022 - ACS Publications
The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is overexpressed in several tumor
entities, promotes tumorigenesis and tumor progression, and has been suggested to worsen …