Over the last century, several morphological models of forebrain organization have been
proposed that hypothesize alternative topological solutions for the relationships of the …

▪ Abstract Recent embryological studies are beginning to establish that the underlying
organization of the forebrain may be reduced to relatively simple elements that are common …

The mouse Mash-7 gene, like its Drosophila homologs of the achaete-scute complex (AS-
C), encodes a transcription factor expressed in neural precursors. We created a null allele of …

The cellular interactions that control the differentiation of dorsal cell types from neural
progenitors have been examined in neural plate explants. Certain genes that are expressed …

The NEUROGENINS (NGNs) are neural-specific basic helix–loop–helix (bHLH) transcription
factors. Mouse embryos lacking ngn1 fail to generate the proximal subset of cranial sensory …

In the accompanying paper, we show that the expression of a dominant negative activin
receptor can convert prospective ectoderm into neural tissue, which suggests that activin is …

Several bHLH proteins are involved in vertebrate neurogenesis, but those controlling early
stages of neuronal determination have not yet been identified. Here we describe a novel …

In Drosophila, the proneural genes of the achaete-scute complex encode transcriptional
activators that can commit cells to a neural fate. We have isolated cDNAs for two Xenopus …

Here we report the isolation of a rat cDNA clone, Jagged, which we show encodes a ligand
for vertebrate Notch. Our conclusion is based on three observations. First, sequence …

Several major advances in the understanding of the regulation of vertebrate neurogenesis
by members of the basic helix-loop-helix (bHLH) protein family have been made in the past …