A better understanding of the sequential and temporal aspects in which diseases occur in
patient's lives is essential for developing improved intervention strategies that reduce …

Many diseases show patterns of co-occurrence, possibly driven by systemic dysregulation of
underlying processes affecting multiple traits. We have developed a method (treeLFA) for …

Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined
condition encompassing hepatic steatosis and metabolic dysfunction. However, the …

Importance Since its inception under Kraepelin in the modern era, diagnostic stability and
familial/genetic risk have been among the most important psychiatric nosologic validators …

Background Patients diagnosed with ischemic heart disease (IHD) are becoming
increasingly multi-morbid, and studies designed to analyze the full spectrum are few …

Background Given the increased risk of chronic diseases and comorbidity among middle-
aged and older adults in China, it is pivotal to identify the disease trajectory of developing …

Pancreatic cancer is one of the deadliest cancer types with poor treatment options. Better
detection of early symptoms and relevant disease correlations could improve pancreatic …

Background Neuroticism is a psychological personality trait that has a significant impact on
public health and is also a potential predisposing factor for adverse disease outcomes; …

This paper describes the implementation of a comprehensive clinical decision support
system (CDSS) for the risk factors prediction of comorbidities related to obesity and for the …

Predicting the trajectory of a disease at an early stage can aid physicians in offering effective
treatment, prompt care to patients, and also avoid misdiagnosis. However, forecasting …