Peroxisomal L-bifunctional enzyme (EHHADH) plays a role in the classic peroxisomal fatty
acid β-oxidation pathway; however, the relationship between EHHADH expression and …

Male sex is a risk factor for progression of diabetic kidney disease, but the reasons for this
predilection are unclear. Here, we demonstrate that cell sex and sex hormones alter the …

Chronic kidney disease (CKD) affects millions of people worldwide and is characterizedby a
reduction in glomerular filtration rate and albuminuria resulting in a gradual loss ofkidney …

Mitochondrial dysfunction has recently been linked to the onset and progression of
pulmonary fibrosis. In patients with Idiopathic Pulmonary Fibrosis (IPF), fibroblasts exhibit …

A combination of in vitro assays and animal models are used to evaluate the properties of
novel drug molecules, including safety and efficacy, throughout the drug development …

Purpose of review: Diabetic kidney disease (DKD), a leading cause of end-stage kidney
disease, is the result of metabolic network alterations in the kidney. Therefore, metabolomics …

Renal fibrosis is a common pathological endpoint in chronic kidney disease (CKD) that is
challenging to reverse. Although myofibroblasts are mainly responsible for the accumulation …

UNIVERSITY OF PENNSYLVANIA - PERELMAN SCHOOL OF MEDICINE Curriculum Vitae
Date: 08/11/2023 Mingyao Li, Ph.D. Address: Unive Page 1 UNIVERSITY OF PENNSYLVANIA …

Fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of
chronic kidney disease (CKD). Myofibroblasts, which are the cells responsible for ECM …