Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute
kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal …

Inflammation is a common feature of all forms of chronic kidney disease; however, the
underlying mechanism remains poorly understood. Evolutionarily inherited endogenous …

Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The
kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis …

Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …

Background Mouse models have been widely used to understand kidney disease
pathomechanisms and play an important role in drug discovery. However, these models …

Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin.
We extend this concept to identify cell types of origin using the Tabula Sapiens …

Methods We used data on the renal gluconeogenic pathway from more than 200 renal
biopsies performed on CKD patients and from 43 kidney allograft patients, and studied three …

Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-
specific epigenomic annotations and 3D genome information we generated and validated …

Fibrosis is the progressive accumulation of excess extracellular matrix and can cause organ
failure. Fibrosis can affect nearly every organ including kidney and there is no specific …

Angiotensin receptor blockers (ARBs) and sodium-glucose cotransporter 2 inhibitors
(SGLT2i) have been used as the standard therapy for patients with diabetic kidney disease …