The kidney, and in particular the proximal tubule (PT), has a high demand for ATP, due to its
function in bulk reabsorption of solutes. In normal PT, ATP levels are predominantly …

Diabetes is the leading cause of kidney disease that progresses to kidney failure. However,
the key molecular and cellular pathways involved in diabetic kidney disease (DKD) …

Chronic disease processes are marked by cell-specific transcriptomic and epigenomic
changes. Single nucleus joint RNA-and ATAC-seq offers an opportunity to study the gene …

Profibrotic proximal tubules (PT) were identified as a unique phenotype of proximal tubule
cells (PTCs) in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the …

The kidney has a remarkable regenerative capacity. In response to ischemic or toxic injury,
proximal tubule cells can proliferate to rebuild damaged tubules and restore kidney function …

Precise coupling between cellular physiology and metabolism is emerging as a vital
relationship underpinning tissue health and longevity. Nevertheless, functional-metabolic …

Kidney fibrosis is the final common pathway of virtually all chronic kidney diseases (CKDs)
and is therefore considered to be a promising therapeutic target for these conditions …

The generation of kidney organoids from human pluripotent stem cells (hPSCs) has
represented a relevant scientific achievement in the organoid field. Importantly, hPSC …

The kidney epithelium, with its intricate arrangement of highly specialized cell types,
constitutes the functional core of the organ. Loss of kidney epithelium is linked to the loss of …

Background Proximal tubular (PT) cells are enriched in mitochondria and peroxisomes.
Whereas mitochondrial fatty acid oxidation (FAO) plays an important role in kidney function …