The kidney epithelium, with its intricate arrangement of highly specialized cell types,
constitutes the functional core of the organ. Loss of kidney epithelium is linked to the loss of …

Altered lipid metabolism is a characteristic feature and potential driving factor of acute
kidney injury (AKI). Of the lipids that accumulate in injured renal tissues, ceramides are …

Cellular senescence contributes to inflammatory kidney disease via the secretion of
inflammatory and profibrotic factors. Protease‐activating receptor 2 (PAR2) is a key regulator …

Kidney injury and repair are accompanied by significant disruptions in metabolic pathways,
leading to renal cell dysfunction and further contributing to the progression of renal …

Fibrosis is the tissue scarring characterized by excess deposition of extracellular matrix
(ECM) proteins, mainly collagens. A fibrotic response can take place in any tissue of the …

Kidney epithelial cells have very high energy requirements, which are largely met by fatty
acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney …

Macrophages are a key component of the renal mononuclear phagocyte system, playing a
major role in defense against infection, renal injury and repair. Yolk sac macrophage …

Successfully targeting aberrant Wnt signaling in cancer, and even more so in chronic
diseases, requires a fine balancing act, wherein the 'dark side'of Wnt signaling in disease …

Fatty acid metabolism, including β-oxidation (βOX), plays an important role in human
physiology and pathology. βOX is an essential process in the energy metabolism of most …

The orphan nuclear receptor ERRα is the most extensively researched member of the
estrogen-related receptor family and holds a pivotal role in various functions associated with …