Multimodal characterization of sexual dimorphism in the mammalian kidney
H Li, BD Humphreys - Kidney international, 2024 - pubmed.ncbi.nlm.nih.gov
[HTML][HTML] Differential Kat3 usage orchestrates the integration of cellular metabolism with differentiation
X Hu, M Ono, NO Chimge, K Chosa, C Nguyen… - Cancers, 2021 - mdpi.com
Simple Summary The coupling of metabolism with cellular status is critically important and
highly evolutionarily conserved. However, how cells coordinate metabolism with …
highly evolutionarily conserved. However, how cells coordinate metabolism with …
A diabetic milieu increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients
SARS-CoV-2 infections lead to a high risk of hospitalization and mortality in diabetic
patients. Why diabetic individuals are more prone to develop severe COVID-19 remains …
patients. Why diabetic individuals are more prone to develop severe COVID-19 remains …
Dissecting nephron morphogenesis using kidney organoids from human pluripotent stem cells
E Garreta, Z Nauryzgaliyeva, A Marco, W Safi… - Current Opinion in …, 2022 - Elsevier
Highlights•Current understanding of human nephron morphogenetic programs is
limited.•Tissue mechanics and cell fate specification may act in concert to shape the …
limited.•Tissue mechanics and cell fate specification may act in concert to shape the …
[HTML][HTML] Controlling cellular plasticity to improve in vitro models for kidney regeneration
CP Casellas, MB Rookmaaker, MC Verhaar - Current Opinion in …, 2021 - Elsevier
Given the increasing prevalence of end-stage kidney disease, the high morbidity and
mortality of dialysis treatment, and the shortage of donor kidneys, the field of nephrology is …
mortality of dialysis treatment, and the shortage of donor kidneys, the field of nephrology is …
[HTML][HTML] Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
M Ganji-Arjenaki, Z Kamali, E Evangelou… - Kidney International …, 2024 - Elsevier
Introduction Blood pressure (BP) is a highly heritable trait with over 2000 underlying
genomic loci identified to date. Although the kidney plays a key role, little is known about …
genomic loci identified to date. Although the kidney plays a key role, little is known about …
[HTML][HTML] Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells
This protocol presents the use of SARS-CoV-2 isolates to infect human kidney organoids,
enabling exploration of the impact of SARS-CoV-2 infection in a human multicellular in vitro …
enabling exploration of the impact of SARS-CoV-2 infection in a human multicellular in vitro …
Lupus nephritis
A Davidson - Dubois' Lupus Erythematosus and Related Syndromes, 2025 - Elsevier
Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus
erythematosus (SLE). The mechanisms of renal damage are complex. LN is characterized …
erythematosus (SLE). The mechanisms of renal damage are complex. LN is characterized …
Cell types of origin in the cell free transcriptome in human health and disease
SK Vorperian, MN Moufarrej… - BioRxiv, 2021 - biorxiv.org
Liquid biopsies using cell-free RNA (cfRNA) can noninvasively measure dynamic
physiological changes throughout the body. While there is much effort in the liquid biopsy …
physiological changes throughout the body. While there is much effort in the liquid biopsy …
[HTML][HTML] Harnessing the Full Potential of Multi-Omic Analyses to Advance the Study and Treatment of Chronic Kidney Disease
C Hill, I Avila-Palencia, AP Maxwell, RF Hunter… - Frontiers in …, 2022 - frontiersin.org
Chronic kidney disease (CKD) was the 12th leading cause of deaths globally in 2017 with
the prevalence of CKD estimated at~ 9%. Early detection and intervention for CKD may …
the prevalence of CKD estimated at~ 9%. Early detection and intervention for CKD may …