[PDF][PDF] Large scale multiple kernel learning

S Sonnenburg, G Rätsch, C Schäfer… - The Journal of Machine …, 2006 - jmlr.org
While classical kernel-based learning algorithms are based on a single kernel, in practice it
is often desirable to use multiple kernels. Lanckriet et al.(2004) considered conic …

Fast model-based protein homology detection without alignment

S Hochreiter, M Heusel, K Obermayer - Bioinformatics, 2007 - academic.oup.com
Motivation: As more genomes are sequenced, the demand for fast gene classification
techniques is increasing. To analyze a newly sequenced genome, first the genes are …

[HTML][HTML] Prediction of the functional class of metal-binding proteins from sequence derived physicochemical properties by support vector machine approach

HH Lin, LY Han, HL Zhang, CJ Zheng, B Xie, ZW Cao… - BMC …, 2006 - Springer
Metal-binding proteins play important roles in structural stability, signaling, regulation,
transport, immune response, metabolism control, and metal homeostasis. Because of their …

Homology-free prediction of functional class of proteins and peptides by support vector machines

YZ Chen, F Zhu, LY Han, X Chen… - Current Protein and …, 2008 - ingentaconnect.com
Protein and peptide sequences contain clues for functional prediction. A challenge is to
predict sequences that show low or no homology to proteins or peptides of known function …

Kernel Functions for Attributed Molecular Graphs–A New Similarity‐Based Approach to ADME Prediction in Classification and Regression

H Fröhlich, JK Wegner, F Sieker… - QSAR & Combinatorial …, 2006 - Wiley Online Library
Kernel methods, like the well‐known Support Vector Machine (SVM), have received growing
attention in recent years for designing QSAR models that have a high predictive strength …

Large scale genomic sequence SVM classifiers

S Sonnenburg, G Rätsch, B Schölkopf - Proceedings of the 22nd …, 2005 - dl.acm.org
In genomic sequence analysis tasks like splice site recognition or promoter identification,
large amounts of training sequences are available, and indeed needed to achieve …

[HTML][HTML] Prediction of the functional class of lipid binding proteins from sequence-derived properties irrespective of sequence similarity

HH Lin, LY Han, HL Zhang, CJ Zheng, B Xie… - Journal of lipid …, 2006 - ASBMB
Lipid binding proteins play important roles in signaling, regulation, membrane trafficking,
immune response, lipid metabolism, and transport. Because of their functional and …

Automated classification of the behavior of rats in the forced swimming test with support vector machines

H Fröhlich, A Hoenselaar, J Eichner, H Rosenbrock… - Neural Networks, 2008 - Elsevier
The forced swimming test of rats or mice is a frequently used behavioral test to evaluate
compounds for antidepressant activity in vivo. The aim of this study was to replace the …

Prediction of functional class of proteins and peptides irrespective of sequence homology by support vector machines

ZQ Tang, HH Lin, HL Zhang, LY Han… - … and biology insights, 2007 - journals.sagepub.com
Various computational methods have been used for the prediction of protein and peptide
function based on their sequences. A particular challenge is to derive functional properties …

[PDF][PDF] Machine Learning for Genomic Sequence Analysis

S Sonnenburg - 2009 - depositonce.tu-berlin.de
With the development of novel sequencing technologies, the way has been paved for cost
efficient, high-throughput whole genome sequencing. In the year 2008 alone, about 250 …