Motivation: As more genomes are sequenced, the demand for fast gene classification techniques is increasing. To analyze a newly sequenced genome, first the genes are …
Metal-binding proteins play important roles in structural stability, signaling, regulation, transport, immune response, metabolism control, and metal homeostasis. Because of their …
Protein and peptide sequences contain clues for functional prediction. A challenge is to predict sequences that show low or no homology to proteins or peptides of known function …
H Fröhlich, JK Wegner, F Sieker… - QSAR & Combinatorial …, 2006 - Wiley Online Library
Kernel methods, like the well‐known Support Vector Machine (SVM), have received growing attention in recent years for designing QSAR models that have a high predictive strength …
In genomic sequence analysis tasks like splice site recognition or promoter identification, large amounts of training sequences are available, and indeed needed to achieve …
Lipid binding proteins play important roles in signaling, regulation, membrane trafficking, immune response, lipid metabolism, and transport. Because of their functional and …
H Fröhlich, A Hoenselaar, J Eichner, H Rosenbrock… - Neural Networks, 2008 - Elsevier
The forced swimming test of rats or mice is a frequently used behavioral test to evaluate compounds for antidepressant activity in vivo. The aim of this study was to replace the …
Various computational methods have been used for the prediction of protein and peptide function based on their sequences. A particular challenge is to derive functional properties …
With the development of novel sequencing technologies, the way has been paved for cost efficient, high-throughput whole genome sequencing. In the year 2008 alone, about 250 …