Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic
properties that can differentially promote progression, metastasis and drug resistance …

One of the most fundamental questions in biology is what types of cells form different tissues
and organs in a functionally coordinated fashion. Larger-scale single-cell sequencing and …

New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …

Intratumor heterogeneity is a common characteristic across diverse cancer types and
presents challenges to current standards of treatment. Advancements in high-throughput …

RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative
analysis of messenger RNA molecules in a biological sample and is useful for studying …

As single-cell RNA-sequencing (scRNA-seq) datasets have become more widespread the
number of tools designed to analyse these data has dramatically increased. Navigating the …

In the last decades, transcriptome profiling has been one of the most utilized approaches to
investigate human diseases at the molecular level. Through expression studies, many …

The excessive amount of zeros in single-cell RNA-seq (scRNA-seq) data includes 'real'zeros
due to the on-off nature of gene transcription in single cells and 'dropout'zeros due to …

Cellular heterogeneity within and across tumors has been a major obstacle in
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …