Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

With the high morbidity and mortality, hepatocellular carcinoma (HCC) represents a major
yet growing burden for our global community. The relapse-prone nature and drug resistance …

Senescent cells have long been associated with deleterious effects in aging-related
pathologies, although recent studies have uncovered their beneficial roles in certain …

For many adult human organs, tissue regeneration during chronic disease remains a
controversial subject. Regenerative processes are easily observed in animal models, and …

The purpose of this review is to summarize current knowledge about the role of the
Hedgehog signaling pathway in liver homeostasis and disease. Hedgehog is a …

Targeting senescent hepatocytes using the thrombomodulin-PAR... : Hepatology Targeting
senescent hepatocytes using the thrombomodulin-PAR1 inhibitor vorapaxar ameliorates …

Non-alcoholic fatty liver disease (NAFLD) represents an increasing global health burden.
Cellular senescence develops in response to cellular injury, leading not only to cell cycle …

Aging is considered the main risk factor for many chronic diseases that frequently appear at
advanced ages. However, the inevitability of this process is being questioned by recent …

Metabolic syndrome (MetS) refers to cardiometabolic risk factors, such as visceral obesity,
dyslipidemia, hyperglycemia/insulin resistance, arterial hypertension and non-alcoholic fatty …

Accumulation of senescent cells may drive age-associated alterations and pathologies.
Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here …