HIV infection

LG Bekker, C Beyrer, N Mgodi, SR Lewin… - Nature Reviews …, 2023 - nature.com
The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

Origins of HIV and the AIDS pandemic

PM Sharp, BH Hahn - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …

Zoonotic spillover: Understanding basic aspects for better prevention

JH Ellwanger, JAB Chies - Genetics and Molecular Biology, 2021 - SciELO Brasil
The transmission of pathogens from wild animals to humans is called “zoonotic spillover”.
Most human infectious diseases (60-75%) are derived from pathogens that originally …

The impact of Covid-19 on the insurance industry

P Babuna, X Yang, A Gyilbag, DA Awudi… - International journal of …, 2020 - mdpi.com
This study investigated the impact of COVID-19 on the insurance industry by studying the
case of Ghana from March to June 2020. With a parallel comparison to previous pandemics …

The early spread and epidemic ignition of HIV-1 in human populations

NR Faria, A Rambaut, MA Suchard, G Baele, T Bedford… - science, 2014 - science.org
Thirty years after the discovery of HIV-1, the early transmission, dissemination, and
establishment of the virus in human populations remain unclear. Using statistical …

The origin and diversity of the HIV-1 pandemic

J Hemelaar - Trends in molecular medicine, 2012 - cell.com
This review examines the enormous progress that has been made in the past decade in
understanding the origin of HIV, HIV genetic variability, and the impact of global HIV diversity …

HIV-TRACE (TRAnsmission Cluster Engine): a tool for large scale molecular epidemiology of HIV-1 and other rapidly evolving pathogens

SL Kosakovsky Pond, S Weaver… - Molecular biology …, 2018 - academic.oup.com
In modern applications of molecular epidemiology, genetic sequence data are routinely
used to identify clusters of transmission in rapidly evolving pathogens, most notably HIV-1 …

1970s and 'Patient 0'HIV-1 genomes illuminate early HIV/AIDS history in North America

M Worobey, TD Watts, RA McKay, MA Suchard… - Nature, 2016 - nature.com
The emergence of HIV-1 group M subtype B in North American men who have sex with men
was a key turning point in the HIV/AIDS pandemic. Phylogenetic studies have suggested …

Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960

M Worobey, M Gemmel, DE Teuwen, T Haselkorn… - Nature, 2008 - nature.com
Human immunodeficiency virus type 1 (HIV-1) sequences that pre-date the recognition of
AIDS are critical to defining the time of origin and the timescale of virus evolution,. A viral …

Evolutionary analysis of the dynamics of viral infectious disease

OG Pybus, A Rambaut - Nature Reviews Genetics, 2009 - nature.com
Many organisms that cause infectious diseases, particularly RNA viruses, mutate so rapidly
that their evolutionary and ecological behaviours are inextricably linked. Consequently …