Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …

The complexity of glioblastoma multiforme, the most common and lethal variant of gliomas,
is reflected by cellular and molecular heterogeneity at both the inter-and intra-tumoural …

Despite extensive study, few therapeutic targets have been identified for glioblastoma
(GBM). Here we show that patient-derived glioma sphere cultures (GSCs) that resemble …

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …

PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show
that Wnt ligand and activated EGFR induce the binding of the β-catenin/TCF/LEF complex to …

Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary
brain tumor. GBM is characterized by an infiltrating growth nature, abundant vascularization …

There has been increasing awareness that glioblastoma, which may seem
histopathologically similar across many tumors, actually represents a group of molecularly …

Glioblastoma (GBM) is the most common malignant adult brain cancer with no curative
treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to …

Background E2F transcription factors are considered to be important drivers of tumour
growth. E2F7 is an atypical E2F factor, and its role in glioblastoma remains undefined …

Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors
have poor 5-year survival for patients. Gliomas are principally characterized by rapid …