Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

As the prevalence of diabetes continues to climb, the number of individuals living with
diabetic complications will reach an unprecedented magnitude. The emergence of new …

Diabetic nephropathy (DN) is the most common chronic kidney disease. Accumulation of
glucose and metabolites activates resident macrophages in kidneys. Resident macrophages …

Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic
patients worldwide. DN is associated with proteinuria and progressive slowing of glomerular …

Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …

Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus which may
eventually lead to end‐stage kidney disease (ESKD). Despite improvements in glycaemic …

Diabetic keratopathy (DK) is an important diabetic complication at the ocular surface.
Chronic low-grade inflammation mediated by the NLRP3 inflammasome promotes …

Sodium-glucose cotransporter2 (SGLT2) inhibitors have a reno-protective effect in diabetic
kidney disease. However, the detailed mechanism remains unclear. In this study, human …

Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and
are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in …