[HTML][HTML] 'Spikeopathy': COVID-19 spike protein is pathogenic, from both virus and vaccine mRNA

PI Parry, A Lefringhausen, C Turni, CJ Neil, R Cosford… - Biomedicines, 2023 - mdpi.com
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to
society. The production of 'safe and effective'vaccines was a key public health target. Sadly …

Multifunctional nanoparticle-mediated combining therapy for human diseases

X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - … and Targeted Therapy, 2024 - nature.com
Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

Incidence and risk factors of myocarditis in hospitalized patients with COVID‐19

K Keller, I Sagoschen, S Konstantinides… - Journal of medical …, 2023 - Wiley Online Library
Myocarditis as cardiac involvement in coronavirus disease 2019 (COVID‐19)‐infection is
well known. Real‐world data about incidence in hospitalized COVID‐19‐patients and risk …

Pathogenic pathways and therapeutic targets of inflammation in heart diseases: A focus on Interleukin‐1

MG Del Buono, A Bonaventura… - European Journal of …, 2024 - Wiley Online Library
Background An exuberant and dysregulated inflammatory response contributes to the
development and progression of cardiovascular diseases (CVDs). Methods This narrative …

Vaccination-associated myocarditis and myocardial injury

NL Altman, AA Berning, SC Mann, RA Quaife… - Circulation …, 2023 - Am Heart Assoc
SARS-CoV-2 vaccine–associated myocarditis/myocardial injury should be evaluated in the
contexts of COVID-19 infection, other types of viral myocarditis, and other vaccine …

COVID-19-induced myocarditis: pathophysiological roles of ACE2 and toll-like receptors

P Pannucci, SR Jefferson, J Hampshire… - International journal of …, 2023 - mdpi.com
The clinical manifestations of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection responsible for coronavirus disease 2019 (COVID-19) commonly include …

Rationale and design of the ARAMIS trial: Anakinra versus placebo, a double blind randomized controlled trial for the treatment of acute myocarditis

M Kerneis, F Cohen, A Combes, Z Amoura… - Archives of …, 2023 - Elsevier
Background Acute myocarditis is an inflammation of the myocardium that can cause life-
threatening events. However, anti-inflammatory strategies did not reduce the risk of clinical …

Immunopathogenesis and immunomodulatory therapy for myocarditis

W He, L Zhou, K Xu, H Li, JJ Wang, C Chen… - Science China Life …, 2023 - Springer
Myocarditis is an inflammatory cardiac disease characterized by the destruction of
myocardial cells, infiltration of interstitial inflammatory cells, and fibrosis, and is becoming a …

Role of genetics in inflammatory cardiomyopathy

PJ Scheel III, I Cartella, B Murray, NA Gilotra… - International Journal of …, 2024 - Elsevier
Traditional cardiomyopathy paradigms segregate inflammatory etiologies from those caused
by genetic variants. An identified or presumed trigger is implicated in acute myocarditis or …

Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis

C Perez-Shibayama, C Gil-Cruz, N Cadosch… - Nature cardiovascular …, 2024 - nature.com
Myocarditis is an inflammatory heart disease that leads to loss of cardiomyocytes and
frequently precipitates fibrotic remodeling of the myocardium, culminating in heart failure …