40 years after the registration of acyclovir: do we need new anti-herpetic drugs?

A Majewska, B Mlynarczyk-Bonikowska - International journal of …, 2022 - mdpi.com
Herpes simplex virus types 1 and 2 HSV1 and 2, namely varicella-zoster VZV and
cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in …

[HTML][HTML] Cytomegalovirus infection in transplant recipients: newly approved additions to our armamentarium

F Khawaja, A Spallone, CN Kotton… - Clinical Microbiology and …, 2023 - Elsevier
Background The burden that cytomegalovirus (CMV) portends for haematopoietic and solid-
organ transplant recipients cannot be understated. Valganciclovir and ganciclovir have …

Drug resistance assessed in a phase 3 clinical trial of maribavir therapy for refractory or resistant cytomegalovirus infection in transplant recipients

S Chou, S Alain, C Cervera, RF Chemaly… - The Journal of …, 2024 - academic.oup.com
Background This drug resistance analysis of a randomized trial includes 234 patients
receiving maribavir and 116 receiving investigator-assigned standard therapy (IAT), where …

Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial …

GA Papanicolaou, RK Avery… - Clinical Infectious …, 2024 - academic.oup.com
Background Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus
(CMV) infection following hematopoietic cell transplant (HCT). A phase 2 study indicated …

[HTML][HTML] New treatment options for refractory/resistant CMV infection

CS Walti, N Khanna, RK Avery… - Transplant …, 2023 - frontierspartnerships.org
Despite advances in monitoring and treatment, cytomegalovirus (CMV) infections remain
one of the most common complications after solid organ transplant (SOT). CMV infection …

New perspectives on antimicrobial agents: maribavir

V Halpern-Cohen, EA Blumberg - Antimicrobial agents and …, 2022 - Am Soc Microbiol
Maribavir was approved by the US Food and Drug Administration in November 2021 for the
treatment of adult and pediatric patients with post-transplant cytomegalovirus (CMV) …

Adoptive immunotherapy for prophylaxis and treatment of cytomegalovirus infection

CP Ouellette - Viruses, 2022 - mdpi.com
Cytomegalovirus (CMV), a member of the Herpesviridae family, is frequent among
hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients in absence …

How I prevent viral reactivation in high-risk patients

SS Dadwal, GA Papanicolaou… - Blood, The Journal of …, 2023 - ashpublications.org
Preventing viral infections at an early stage is a key strategy for successfully improving
transplant outcomes. Preemptive therapy and prophylaxis with antiviral agents have been …

Development and validation of a next-generation sequencing assay with open-access analysis software for detecting resistance-associated mutations in CMV

MA Mallory, WC Hymas, KE Simmon… - Journal of Clinical …, 2023 - Am Soc Microbiol
Cytomegalovirus (CMV) resistance testing by targeted next-generation sequencing (NGS)
allows for the simultaneous analysis of multiple genes. We developed and validated an …

Evaluating the Safety of Maribavir for the Treatment of Cytomegalovirus

RG Gandhi, CN Kotton - Therapeutics and Clinical Risk …, 2022 - Taylor & Francis
Purpose of Review Cytomegalovirus (CMV) infections are a common complication in solid
organ (SOT) and hematopoietic stem cell transplant (HSCT) recipients, leading to increased …